How I Looked Beyond the Stars

dedicated four years of a mathematics PhD to studying the distant (1.5×10^8m away to be precise) mass we refer to as ‘The Sun’, desperately trying to make or simulate complicated measurements that my peers wouldn’t instantly disbelieve. Nevertheless, I felt an urge to study a subject somewhat closer to my home. Maybe one that might have an impact on my own environment, where I live and thrive, my family, or even the local shopkeeper’s. Basically anything where I didn’t have to show patience for the next ten billion years to see an effect.

Change your mind: obesity and type 1 diabetes

Diabetes is a chronic disease of carbohydrate, fat and protein metabolism that results from the inadequate action of insulin. It affects an estimated 463 million people worldwide and is predicted to rise to approximately 578 million people by 20301. Dangerous acute complications of diabetes include diabetic ketoacidosis and severe hypoglycemia (low blood glucose), which can lead to a trip to the emergency room or worse.  In the long-term, chronic hyperglycemia (high blood glucose) can lead to a number of micro- and macro- vascular complications, including nephropathy, retinopathy, coronary artery disease, stroke and peripheral neuropathy.

Obesity, a risk factor for symptom severity

The main topic of interest within SOPHIA’s WP3 is to assess the risk factors involved in obesity.  However, obesity itself is a well-known risk factor of other diseases. For example, obesity has been considered a long-term risk factor for chronic diseases such as cardiovascular disease and diabetes; on the other hand, obesity is considered a risk factor for acute diseases as well.

The foundation for analysis across cohorts: a common data model

One of the objectives within SOPHIA WP2 is to harmonise and standardise obesity cohorts and link them into a federated database system to allow for analysis across cohorts. The crucial benefit of the federated database is that the individual cohorts can stay locally on edge nodes, while a central server along with specialized software can learn models across nodes, while preserving privacy and security.

“I am terrified of something happening to me” The lived experience of people with obesity during the COVID‐19 pandemic

Congratulations to Work Package 7 working group for publishing some of their research work carried out as part of SOPHIA. The research highlights the lived experiences of people living with obesity during the COVID-19 pandemic. It highlights the challenge sustaining treatment and psychosocial impact during these unprecedented times.

A Q&A about SOPHIA with Prof. Carel le Roux

The Innovative Medicine Initiative has published an article about the work we do in SOPHIA and it impacts on the diabetes epidemic. The article includes a Q&A with Prof Carel le Roux, Project Coordinator. 

SOPHIA Welcome Webinar: COVID-19 will not slow us down!

The COVID-19 pandemic has caused many events around the world to be cancelled or postponed and SOPHIA also had its share. SOPHIA’s Kick-Off meeting was originally planned to take place in Denmark last month but it had to be postponed to a later ‘yet to be confirmed’ date.

NEAR fm Interview with Carel le Roux

Prof Carel le Roux, Coordinator of SOPHIA, spoke on Irish Radio NEAR fm about the SOPHIA project and how it aims to change the treatments of obesity. 

Press Release

New €16 million EU and industry-supported international research consortium aims to improve obesity treatment and change the narrative around obesity